How difficult is it to make clone from tetraploid or hexaploid.

First generation plants that have been treated with colchicine are unsafe to smoke. The plant will be no more potent than the original. Clones should be as straight forward as with normal plants. It is only safe to smoke polyploid plants that have been grown from seeds produced by polyploid parents. Polyploidism only affects size/growth and vigor of the plant, but not THC production, sadly. If it did create super resinous plants, they would have been on the market for decades already.