It's the canopy you want to selectively remove (+lower nodes that produce trash), and i'd wager more conservatively with an autoflower. most of your top/large leaves are still blocking most light.
First grow, so I'd suggest limiting too many technicques to provide a good baseline. Although if not cloning that plant, genetic diversity is going to make that a long-term endeavour. Then, as you try something new, you can see the difference or if it is too small to notice and within a normal range of variance.
the diffiuculty with defoliating an autoflower is the timing. You cut off those top leaves and at least some portion doesn't grow back, i.e. too late into flowering, then that cola is going to suffer without solar panels nearby - they just don't have to be ginormous. When you take off lower nodes or even higher bits to focus resources on best colas, you have no idea when it's done growing beyond a good guess.
If an otherwise strongly growing axuliary branch is blocked from light, free it up. If you do it for specific branches like that, the timing won't matter much. Act as if it won't grow back, so leave some behind on each cola.