Personally, I never defoliate...........if your plant would not need those leaves, it would not grow them in the first place!
The leaves are the solar panels that power the bud growth and the buds will grow out from under the leaves anyhow.
Try and only ever remove yellow leaves, for by the time they are yellow, they have served their purpose.
Just remember,
Maximum amount of healthy green leaves = maximum amount of energy production = maximum amount of (bud) growth.
However, some light, well considered "lollipopping" can be done during early flower, no problem.