Yes it is safe to do a little defoliation. Since your tent is so packed full at the moment it would be a very good thing to do at this point to help increase airflow to prevent mold growth.
It looks like you may have installed your net a little early, it is fine to have one at that level but I would have put another one in to help support the plant up high.
It might be time to raise the lights up a little bit, it looks like the plant grew right up there.
As far as humidity during flower, you would want to keep it under 60%. This will help eliminate the potential of mold and mildew.
I hope this helps.