Hey Wizthc, that’s a great question and a common debate among growers. Personally, I always recommend waiting at least 3 to 5 days after a heavy session of topping or lollipoping before you flip to 12/12. You want the plant to show signs of active growth again and "bounce back" so it can focus all its energy on the upcoming stretch and flower production rather than healing wounds. If you flip while she's still stressed, it can lead to stunted growth or even hermies if the genetics are sensitive. As for how much to do, lollipoping usually involves clearing out the bottom third of the plant where light doesn't penetrate well, which helps with airflow and prevents "popcorn" buds. For defoliation, just focus on removing large fan leaves that are blocking major bud sites. Doing a light cleanup now and then a final defoliation around day 21 of flower is a solid strategy to keep things managed without overstressing her. Happy Growing Growmie🌱