I would say its either rust spots or a root problem due too overfeed or high ph maybe.
That being said what are your temps ect... during night ensure around 18° to help lower chances of bacterial issues with the roots which you may allready have.
Luckily I've had this issue but not as bad, I'd suggest keeping lights slightly lower setting or higher if no dimmer, then feed plain ph water not even calmag! This will help flush some negative chemicals.
I personally had minor spots which after a small flush essentially, they grew out and became healthy but this may not be the same for you as its alot worse than what I had