I'm not a big fan of defoliation, because for us it"s just plucking some leaves off, but for the plant it's high stress training basically ripping a piece of the plant off, right? so then what happens is the plant focusses on healing itself, making more leaves, getting stressed... especially now during your flower stretch you want it to grow and make flower nodes not leaves, right? I would definitely wait until the flower stretch is over before you stress her, then i would still choose to prune flower nodes lower on the branches, liable to be popcorn buds or smaller nugs. pruning these or lollipopping at that point will help the plant focus on bigger, more valuable buds. Does this make any sense ? hope this helps ! 🚀