Keep up on training. Observe and react to leaf symptoms, if still refining formula/methods of fertilziation... easy peasy. If still refining formula, keep up on notes of how you fed and dates etc... when you get near-perfect it takes a month or more for a problem to present itself. the log of info is invaluable.
to avoid remoiving more than 33% of plant at one time, might want to remove the lowest couple nodes now.. then a more thorough examination and pruning around FD15 to FD 18 ish.
Don't defoliate too much. ATP is highly mobile. Leaves are everything! Always have an excellent reason to prune off a leaf.