leaves are a bit dark/glossy in background... maybe inhibiting K a bit? Maybe, just a bit low on K. It should start lower on the plant, which is why i think it may be lockout or possible a bit too much light at top. Damage starting on serated tips is usually k-related.
if you have already reacted and done some things that didn't work, might have contributed to further progression, too. It's important to eliminate as many possibilities before trying multiple things at one time... just makes it harder to diagnose going forward. It'd difficult to take away and easier to give.