I think you'd fill out that space as is... but whatever floats your boat.
don't overcrowd a canopy. More branches does not = more yield. After a point all you do is create excess competition and dense foliage with a higher risk of infection. It's a "goldilocks zone" idea, not "more is better"
~3 colas per sq ft will maximize your yield, if the canopy fills the entire space alotted. The light absorbed is single greatest correlating factor to yield. After that you just need 'enough' colas to distribute and use that energy absorbed by the canopy. You really can't circumvent 50-70g/sq ft with ambient co2. genetics and environment play huge roles, but lets pretend those are 'optimal' for an easier discussion about this one topic. So, if 50-70g/sq ft is the ceiling, you just need enough colas to allow that to happen. AFter that point all you do is spread out growth more and get smaller buds. Bigger buds is not always better,not saying that either - those unusually large colas invite infection too.
by not overcrowding you also eliminate a lot of work -- you'll prune off less stuff, which also means less wasted time and resources on growth you'll never make use of.
Take the guesswork out of it. That's a 4x4? so you want about 50 colas or about 12 each.. for symmetry you could go to 16 each if you wanted. Evenly space those branches out and let them go vertical around flip. Simple as that. prune off anything below initial bends / horizontal training. About 2 weeks into flower, lolipop weak axillary growth at bottom... probably won't have to take off more than 1-3 nodes. With 3x stretchers, can take off a bit more than the 2x stretchers. Take off too much and you hurt yield. I try to leave the ones that look like they'll have enough vascular tissue to produce a meaningful cola and not need support to avoid hanging down to the ground.