older leaf near bottom, possibly close to medium?
I'd wait for this to progress before reacting. Old leaves aren't as well-maintained by the plant and if it's close to an often moist medium, it can impact transpiration of that leaf -- i.e. local issue. I wouldn't remove it.. just let it go for now.
Also.. there are calcium related problems and then there are magnesium related problems. there are no cal-mag problems. They can coincide with each other, but that's not how we label this stuff. They are to unique atoms with different visible symptoms. Mg deficiency takes 4-6 weeks from the actual physical deficiency to see leaf symptoms. If they coincide with calcium problems, they didn't even start at the same time, lol.
Get a leaf symptom chart. google image search can help. Ask all the questions you want, but start looking at it and comparing.. seeing the deductive rasoning to help diagnose... realize that leaf symptoms are not discrete and you need more info than that to confidently diagnose a problem.
This 'could' be the start of some ca deficiency, but i'd be patient and see how it progresses, if it progresses. Where it happens on the plant and how it progresses helps diagnose, too.
Just because a nutrient formula works for some period of time does not mean it works long-term... a slow buildup or deficiency might takes months to cause a symptom. You learn a lot about a formula the longer you use it. if symptoms arise while controlling all other factors (something you can pretty much do with soilless/hydro context), that means the formula is out of balance. doesn't matter if it took 1 week or 2 months to cause a visible symptom. Though how long it takes is relevant to the scale of reaction.