In the first 2 weeks of flowering, do not defoliate. The plant needs the nutrients for a good stretch to begin. In the 3rd week, you can then defoliate and give the plant a few days of rest. From then until weeks 6-8, you can minimally defoliate every 2-3 days. 6-8 weeks because it depends on what strain you are growing. Some flower for 10-13 weeks and others for 8. 1-2 weeks before the end of flowering, do not trim anymore, just remove yellow/dead leaves 👌🏼👶🏻👌🏼