In my opinion, autoflowers are only the ideal choice when you don't have the right conditions to grow photoperiod or regular plants.
Photoperiod plants give the grower much more control, especially indoors. You decide how long the plant stays in the vegetative stage, when to flip it into flower, and ultimately how large you want it to become before flowering.
Another major advantage is cloning. If you find a phenotype with exceptional traits, you can keep it as a mother plant and take clones for years, preserving those exact genetics. That's something you simply can't do effectively with autoflowers because they continue aging regardless of whether they're cloned.
Autos are also less forgiving. Since their vegetative period is fixed, any stress or mistakes early in life usually reduce the final yield because the plant doesn't have enough time to recover.
Personally, I think regular seeds are still the gold standard for experienced growers. They provide both male and female plants, making them the best choice for breeding, phenotype selection, and preserving strong genetics. Feminized photoperiod seeds are excellent if your goal is producing flowers, but they don't offer the same flexibility for breeding.
That said, I'm not saying autos are bad. They definitely have their place, especially for growers with limited space, limited time, or situations where controlling the light cycle isn't practical. But if all conditions are equal and the goal is maximizing quality, yield, and long-term genetic potential, I'd choose photoperiod or regular plants every time.
By the way, I've recently made a genetic cross and I'm currently testing the results on my page. I'd really appreciate it if you could take a look and let me know what you think. 💚🙏