I'm sure dr. zymes will tell you you can spray their shit on your plants until day before harvest but i wouldn't do that. They have an ad on IG telling you to use it to kill fungus gnats. which everyone knows you use BTI (mosquito bits). So never trust a fungicide/pesticide company, even if they claim to be a less evil one. I would avoid spraying in flower at all costs. But it can be done. Not many things I would spray on them though. Anything with any sort of flavors or essental oils id avoid to not ruing flavor of your flower. just gave me an idea though. thought about if using some cannabis derived essential oils would maybe help. kind of like using hemp twine instead of plastic fiber twine, minimizing how much you'll notice contamination, because it will happen regardless be since its cannabis derived it would be better than having thyme oil or something like that. I had to spray some Potassium bicarbonate mid flower on my outdoor autos this year. Has a slight powdery mildew problem starting. Sprayed it on my cucumbers too and it killed it both on the cannabis and cucumbers and still have those cucumber plants so that was amazing. I did one application hydrogen peroxide solution spray before that too. but that can be a little rough o the plant. so i didn't want to do that again so I tried the potassium. ANYWAY that outdoor bud turned out amazing, and even more potent than my indoor stuff the prior round. and i had a pretty good prior indoor auto run. spider mites idk though. maybe that will kill them. but if there were a bunch of webs in my bud and it were personal id maybe think about doing bubble hash or maybe flower rosin.