Truffle, also called Trufflez or Truffles, is an indica-dominant hybrid strain made by crossing Zkittlez x Cherry Noir. The effects of Truffle are relaxing. Reviewers on Leafly say this weed strain makes them feel sleepy, relaxed, and happy. The dominant terpene is caryophyllene, and Truffle has a tangy, coffee nose with sugary and ammonia notes. Truffle has 20% THC. Medical marijuana patients say Truffle helps with stress, hypertension, and depression.