first, there are genetics. this outlines potential outcomes... low and high water-marks. Things will impact the plant relative to this... some plants are simply trashy and even in optimal conditions they are still trash. so, this isn't something that will drastically change the outcome given common sense contexts... extreme situations being ignored.
temperature does impact the buds. hotter will be fluffier, all other things remaining the same.
VPD needs to be adjusted to stage of life cycle you are in. temp and RH go hand-in-hand. You still want to avoid VPD with extreme heat or RH - as these values are not discrete. consult a google search on this. you'll find a wide range of suggestion and very little of it is based up good research, so it's a guess... VPD is key, but what is optimal is a bit messy. ther are seveal coinciding factors tha tplay along with this too, so it's just a complicated mess. this is why some mope growign 5-10 plants can't resolve such things.. too complicated for such a sample size in addition to a multitude of factors that are not kept the same between grow cycles that add even more volatility that further clouds the picture.
co2 will add to yield. C is the limited factor for growth. so more of it will result in more growth. this will have diminishing returns, even so. 1200-1300ppm, an appropriate vpd for stage of life and a well-balanced feed will definitely maximize yields. is it worth it relative to cost of these things vs loosely avoiding extreme environmental variables? no idea. i'd wager it is not cost efective, but there are good reasons to do it.. maybe space and time is limited, so squeezing out every gram per sq ft becomes more important. life is complicated.