Maybe a little bit but good to watch out. And they look really good. Your plants aren't going to suffer. but they are nearing their hungry point in life. it may be deficiency starting to happen. I notice my plants look a little rough sometimes going into flowers,so i think is normal to see a little bit on inperfectness here and there. but they bounce back from it. Looks like they are getting hungry for nitrogen and maybe more intense light? if not changed light intensity and changed light cycle recently maybe you are not getting enough DLI. there is also another meteric for measuring a plant's bioactivity and it relates to how much heat energy is applied to the plant is called growing degree hours GDH. There are also chill hours(sort or unrelated to cannabis pertaining to indoor growing) but chill hours which in nature kills the cannabis to reproduce through seed the following year, apples need 1000 chill hours/y to produce apples.