Anything done to the plant during the stretch is going to be exaggerated - so generally, don't. Anytime after the stretch, usually around the 3 week mark is when folks like to hit the first round of defoliation. If you need another round for light penetration or airflow then go for it once the plants recover. Otherwise prune as you see fit - whether that is for ease of harvest, appearence, light, or air, or your fancy.