Think of stress of an plant similar to the stress of a human, doesn't matter so much what stress you apply, you are adding to the total cumulative stress, once it reaches a point she will say "screw this, at this rate I'm never going to make it to harvest", with this much stress, she begins to switch from growth to defense.
Jasmonic acid is the hormone responsible for this switch of growth to defense.
Understanding the various different stressors, drought stress, light stress, osmotic stress, heat stress.
Every plant has different thresholds for tolerance, what was good for one might flip another, one might be sensitive to cold due to genetical preference. Likewise for heat etc.
More you grow more you will be able to better judge, giving your plant comfortable conditions will allow you to push the lst more than you normally would, attempting LST under very dry and alrdy stressful conditions could be what send her over the edge.
9 times out of 10 its LST time as its not a very stressful event that will increase jasmonic acid dramatically, but it does increase cumulative stress, which if growing with other problems could be enough to flip. So just be careful and keep an eye. Gluck.