I would not go heavy on defoliation ever. But you are looking a little bushy in there. I would just remove anything that does not look as healthy and is covering bud sties, But don't go more than like 5-10 percent. week 2 of flower is kind of the latest when you want to do this. I would not lollipop anything with a stem thicker than trellis net at this stage. but removing a fan leaf here and there may be better than going in and cutting a bunch at once. maybe start with a few lollipop and a few days later go up top and remove a few old fan leaves