Hey friend,
You could definitely remove those couple big ones with the reddish stems. But looking at your plant as a whole, I wouldn't bother just yet. You've got nice internodal spacing and it looks like all the budsites are getting good light, not many shadows. So I'd leave the leaves to do their photosynthetic duty.
Pluck em closer to harvest...plus some nice large leaves sometimes make for good photos of the main bud in the end.😁