Hey there dzdr. IMHO it's call mag def and if not checked it will destroy a plant. Its something I deal with every grow. Partly due to using R.O water and not providing calcium and magnesium which is filtered out . Also could be caused by pH imbalance leading to lock out. The good thing about cal-mag supolements is it's hard to over do it. Also check out the stems of the leaves and smaller branches if purple or violet color are showing it's a sign of cal mag def. Hopeful this will help my friend.
CHEERS!!!