GMSgrowsanswered grow question 3 years ago The giggles comes from being a new smoker, not use to getting high. Smoking 50 years, haven't giggled in 49 of those years now. Just good pain relief for me now. Effects on you change, as you get use to thc. After a while it does not intoxicate you any longer. You have receptors in your body, that the only time they light up is when we smoke or ingest thc. Our bodies were made to take thc into the system. 2 types of weed results for the long time smokers is either relaxed and chilled or a motivational get up and going type feeling. That basically depends on if you let your trichs amber for the relaxed effect or take them when their cloudy or white. That gives you more of a creative high.