Problemi foglie brutte!

I agree with Roberts. Always make sure your PH is within range first, But My guess would be she needs food. Only nutrients I see are BioBizz Light mix which has enough nutrient content for around 3-4 weeks growth. Top Candy is a flowering booster and is intended to add to an existing diet. Pure Zym is a soil enhancer that helps break down organic material.

You either have a ph issue going on or she wants more calcium and phosphorus and potassium her diet is changing

My thought is that you're giving too much nitrogen... I'm not familiar with your nutes, though, so can't say definitely... Week 5, pre-flower, I'd start backing off the grow nutes and increasing the bloom nutes. If the problem is getting worse quickly, I'd do a flush, trim off the affected leaves and go from there.. Good luck!