No... it's not the start of senescence.... it's a combination of a potassium deficiency and a calcium deficiency... which will usually show up together right about this point in a grow if you haven't knocked back your nitrogen-rich nutes and increased the amount of P and K they're given (calmag should also be given about once a week). Rather than doing a flush, I would just give her plain pH'd water for a week and then start feeding her again but knocking back on the N and increasing the PK...
The other thing that might be affecting her is the combination of the different nute lines... pick one and stick with it. Different nutes lines don't always mesh with each other as there are different formulations that might react adversely together.... Personally, I dislike FoxFarm very much so that's the one I'd pitch - but your call....
Once you get a handle on the deficiencies, you shouldn't see any more leaves succumbing to the discoloration - but the damaged leaves won't show any improvement... so don't expect that.. focus on the leaves that look ok now...
Good luck