Well, it's got to be an insect of some kind as a nutrient issue or environmental issue wouldn't cause this kind of damage. I'd get some BT and spray that particular area - top and bottom of leaves - just before lights out. If it IS a leaf-chewing bug, it will take one bite, decide to have lunch elsewhere and go off and die... and BT is organic so no worries there...
Good luck - that's just weird!! :-D