Looks like powdery mildew to me. been there a good long while and been spreading at this point.
amputate around it... generously. cover it while you do it so the agitation doesn't put off more spores than necessary.
despiet what you will read out there.. there is no cure.. home-remedy bullshit like the "cornell formula", which has nothing to do with the institution whatsoever, does not work. Nothing will kill it. Even professional-grade fungicides commercial farms have access to have an effectiveness rate of 33% reduction compared to a control group.
wpm is 100% about prevention. Are you hitting dew pointn after lights go off? this would be something to look into... temps/rh in good range? if you get condensation on plants or regular spray it with water, you are asking for trouble even if trouble doesn't find you each time you do it.