Too complicated, keep it simple silly. Forget everything anyone ever blabbered shit to you with regard to mainlining or defoliation.
Understand this.
When a leaf is not utilizing its photosynthetic capacity it can still utilize its full respitorary capacity.
Why is this important?
Photosynthesis is about capturing carbon, during the capture the plant process 10% of all ATP.
If a leaf is photosyhtesizing it cannot perform cellular respiration. The metabolic pathways are different.
Cellular respiration can only function when Photosynthesis does is not occuring within the leaf, this frees up the leafs oxidative capacity which can then be used to process all that partially processed carbon into the 2nd stage of the conversion process and tap into the other 90% of that ATP. The gold mine.
VPD is for daytime. If you hold high rh overnight you prevent most of the cellular respiration from occurring.
When you remove every single leaf that was not fully photosyntheticly active you remove every other leaf that had the potential to be performing cellular respiration (during daylight).
The very second that a leaf uses more energy than it produces the plant will initiate pcd, begin recycling nutrients and detach itself for maximum efficiency.
The total amount of energy that a plant can process in a single cycle is of more importance than how bare you make your stems.
If you need proof of concept you can check my latest diary. 4x80 day autos in 4x4. 👍 all defoliated, there is a why and a when. Until at least 4-5th week of flower I don't touch a single mitochondria power cell until rapid growth is no longer my priority.
Good luck.