I prefer to harvest when there are about 90-95% brown pistils, this will give you flowers with peak THC levels and with peak terpenes too. Waiting to all the pistils have turned brown will give you flowers with reduced THC but with elevated CBD and CBN levels, giving you a more sleepy body stone as opposed to a more clear and psychoactive head high of earlier picked flowers. So it means which type of effect you prefer should be your guide as to when to harvest. Judging harvest maturity by trichome colour alone has many problems, some strains will never have amber trichomes, meaning people are harvesting almost dead plants due to waiting for the often quoted "30% amber". There are some strains that will have 75% amber trichomes after only 4 weeks of flowering and harvesting at 4 weeks would be very disappointing. This is why I base my harvest timing on pistil condition and not trichome colour and have been doing so for 35+ years with no complaints. Besides, pistil colour will reflect truly the plants health, trichome colour does not, and it is plant health that determines trichome composition and not trichome colour, which is more closely related to genetics.
Hope this helps,...............
Organoman.