when i started growing i was using only bio grow and bio bloom , growed some critical orange punch wich made me awfully coughing, few month later i started using top max as well and re growed some criticial orange punch with much better result in term of taste and the fact it no longer make me cough.
so yes with some strain Top-Max can make a huge difference, now i also use other biobizz products as i experienced overall better health with some strains.