I have been defoliating the auto in my grow-box regularly, and honestly need to, to keep humidity and airflow in check.. if you're growing inside the space-bucket, then i can imagine that will also be an issue for you at the later stages of the plant cycle, so it might even be a necessity.. just don't do too many leaves at once, but i have to say mine have never shown any signs of problems after defoliation.. i think it also depends on the genetics, and how strong the plant is, whether something like this will have a big impact or not.
..having said that i have also topped my autoflower, so removing leaves i something i do without even thinking about it ..