Hey
You can start LST now no worries. Don’t worry about stopping her from growing bigger. I did extensive LST on my plants and they got insanely bushy and I was able to manage the height. I was able to get plants to take up close to a square meter in 5 gallon pots and that was no challenge.
Take a look at my Grow diary if your interested to see how the LST will affect the growth. It’s amazing to see.
In terms of defoliating you can as well. Start with the LST first though. At this stage you’ll be defoliating to expose otherwise unexposed growth sites. Humidity shouldn’t be a problem for your not should space at this point.
When you LST you’ll expose more of the plant so less defoliating maybe necessary. Other wise let the fan leaves help the plant veg out for now. You can always trim as you go along and aim for lower growth or growth that is filling in the stems/plant to much not allowing air passage.
The plant is a resilient and if your hesitant start slow and you’ll se she can bounce back quick. Happy Growing.