Hello,
So i think irritation depends a lot on the person, the strain, and lots of other things. I've had plants that were so amazing you barely had to trim it, other than the fan leaves the entire plant was smoke able. Then plants i dried and cured perfectly and it felt like an allergy attack!
One possibility though is were you already in the process of flushing this plant? Or feeding low levels of nutrients? I got some of my worst irritation from plants that i had overfed, and that didn't get a decent flush.
Maybe you grew one of those lucky magic strains....try growing it again and do the same early samples. Find out if it works everytime.👍