Without a diary, it's really hard to say but I think you've got two possibilities... a calcium deficiency or a normal "I'm getting tired and heading towards the end of my life." Check the ph of your runoff... if it is between 6.0 and 6.5, your plant is simply at the end stage of life... if it's out of that range, you've got a deficiency that is caused BY that out-of-range PH... do a flush and get the PH back in balance... micronutrients cannot be absorbed by the plant if the PH is either too high or too low...
Good luck (and start a diary so we will have all the info needed if you have another problem/question!)