DWCHCanswered grow question 5 years ago I defol right from clone/seedling. It's part of my IPM strategy. I don't use any sprays of any kind, have had flowers run through 65-75% humidity with no PM or bud rot to be seen. It also increases the par in the lower canopy, mind you no more than 30% defol max on any given day, and a nute follow up with a few days recovery in between. As a side note, light browsing of the plants can trigger increased resin production to counteract the browsing(defol). It's a natural defence mechanism... Happy growing!