Yes you should be worried... I believe you may have a nutrient lockout situation.. Nutrient lockout will resemble nutrient deficiency. Any yellowing or curling of the leaves also indicate that the plant is experiencing nutrient lockout.
Your cannabis plant might be oversaturated with nutrients. If you don't flush, it might only get worse.. Keep in mind different plants sometimes need/use different things. So you may have one plant that reacts fine and another plant that is being overfed. If I was you I'd just flush for a few days then go back to lighter feeding of like just overdrive and floracoco bloom cut out the grow and big bud. I like using big bud myself but I have found with base nutrients it can be rather strong. I know of people using just big bud during mid-late flower and nothing else.. Big Bud is almost a main nutrient in itself.. Iv'e found a lot more success with the Advanced nutrients line by using 1/2 what they recommend.