Hello and damn. First grow is going really well man. Looks like you have the 'touch'
I asked this question very recently myself, as I didn't do much pruning or defo in my first grow. I was worried about stress in flower and didn't want to push her. Recently, however, I've been told to forget most of what I was told and by someone that way knew way more then the others.
Long story short, go for it, but don't go hog wild. Trimming and defo is stress and too much stress can have consequences. But taking small amounts here and there , including small flowers in later bloom, that you know you won't want (LARF) is just fine. It is heavily suggested that you plan the defo/trimming directly before or after a feed. This way she will recover much faster with the nutrients needed to do so. Cutting during a dry out is not really recommended...just a heads up👍. Anywho, I wouldn't suggest any of this if you were growing with mystery bag seed, but you're not and have solid genetics here. Strong genetics means the girls can take more stress and bounce back faster. Weak genetics, under stress, have the propensity to be problematic and even hermie in certain stressful conditions. Lastly, choose wisely😉. Your fan leaves are still very purposeful, so anything you don't need to take, don't👍. Try to only take what impedes the growth of other shoots and to increase canopy light penetration.
Good luck with whatever course of action you choose! They look stellar and there are good things on the horizon! Drop me a PM if there's anything else, my grow friend. I'll be kicking around. Cheers😉👍