AsNoriuanswered grow question 4 years ago there is one golden rule in successfull defoliation - leave at least one fully matured leaves nod, everything below you can trim.
So answer is No.
Tuck that leave under, expose branches to light, bent top, defoliate OTHER leaves, but better not touch that till he will be next in the grid.
Defoliate in veg you can all time in flower between day 15 and 20 of flower for first wave, second if you need after 20-25 days from first one. Make time to harvest in 3 parts. After each interval you can harm. ( oversimplified )
Tucking is a better technique, especially on small young plants ...
Good luck !