let the space you intend to fill answer that question...
1 cola per 4inch x 4inch square to 6inch x 6inch square -- divide up area and how many colas do you want? split that up as you see fit between your plants.
you want good airflow and light penetration with good spacing of colas, but pack as much as you can in, since a grow cycle takes roughly the same amount of time regardless.. so, maximize it safely :P