What CO2 device you're using?
CO2 is heavy and tends to follow gravity in your grow room unless something is pulling it or pushing it out.
Most would advise to time your releases of CO2 with shutting down any air exits or exhaust.
This CO2 on and Exhaust off timming can obviously bring other issues if not properly adjusted, such as humidity or temperature out of control but that's something you have to check trying.
If you need the AC on while CO2 releasing then try to hang it with some safe distance above the CO2 dispenser and shut down any other exhaust or fan.
If it's not worth to place CO2 dispenser on your room try the CO2 Tabs. They work.