See the photos of the aphid (I think) attack. Onli...

From what you showed that doesn't look like aphid damage. Did you physically see aphids on the underside of the leaves? If you had aphids they would be all over your smaller leaves/buds sucking them dry causing leaf demormities they wouldn't bother with the large fan leave as much.This could be from watering with the lights on and the water droplets became magnified causing burn spots on the leaf. Try to water just the soil or make sure the leaves are dry before the lights come on. You will be removing this leaf at some point. It doesn't look like a deficiency issue either. Just stop defoliating the plant,and let her grow some new leaves. Hope this puts your mind to rest.