Extreme defoliation has killed this plant ability to make energy and be healthy, hence the lower, smaller buds dying prematurely.
What you did in week 10 amounts to plant torture in my opinion!
All of the plants energy that it needs to grow and be healthy is made in the leaves.
Less leaves = less energy = less growth = less health = less yields.
I personally NEVER defoliate and for the last 30+ years only ever remove yellow/brown leaves.
I do however believe in some light, well considered "lollipopping".