If you don't want a lot of popcorn nugs at the bottom of the plant I would definitely defoliate it's very beneficial to the plant, It shouldn't cause stress either, just take a few at a time and she'll be fine.
Yes I would defoliate a little bit not to much at all. Be careful on your nutrients, those yellow curled tips are nutrients burn! Also need to take that tobacco out of your spliffs 👍🤔😜🌱