Just fix it on transplant and it's like it never happened. It'snot a big problem as long as the rootball is not impeded by the wall of the pot. So, as long as it isn't extreme you can ignore it.
seed position could be part of it. Seed can be centered but pops open on side and now it's a cm or 2 off in that direction. Not something to be too concerned about.
It's a myth that you shoudln't 'transplant' an autoflower. First, what we/you do is 'potting up' and should not involve any stress that shocks the plant. I've done 400-500 up-pots and yet to shock a plant. It simply doesn't happen with an iota of common sense and care while doing it. Don't molest the root ball like some priest alone in a room with a choir boy and it'll be fine.
The benefits of a properly sized plant for root development alone is worth it. Avoiding the totally unnecessary complications of watering a small plant in a large pot is worth it. So many negatives from doing it and only a figment of people's imagination why people are hesitant to pot-up an autoflower. Might as well deprive the plant of fertilizer, light, give it ice water, burn the shit out of the lower stem and flush the hell out of the substrate 2 weeks before harvest, if we are going to follow unsubstantiated nonsense.