People’s reaction to weed is rather unpredictable, and that includes the way cannabis influences headaches. For many people, the right type of strain is an effective medicine against headaches and even migraines. For others who use weed for some unrelated condition or just for fun, headaches are an unwelcome side effect. If you have ever had such an experience before, you should probably stay away from the strains that other users describe as more likely to cause headaches.