Whether it’s seeking relief from body aches or starting the day with the right mindset, most people smoke weed to feel good. And some strains strains can do just that—make you feel happy and euphoric even on your worst days. This is possible because our bodies also produce cannabinoids like the ones found in cannabis. You can increase anandamide, one of the naturally occurring endocannabinoids in our body by meditating, doing yoga, exercising, and eating chocolate, to name a few. Smoking the right strain can uplift your spirits even faster, and make it more long-lasting. However, since everyone’s different, you may need to try a few strains before finding the perfect happy weed strain for you. The list below features all the best weed strains guaranteed to leave a huge smile from ear to ear, no matter how you’re feeling.