Heya!
Do you mean in a 4x4? Just looked at the data sheet, I didn’t see a daisy chaining function except for dimming. They are 100W each, typically with QB’s you want 30-35W/sqft for solid coverage. If you’re talking about a 4x4 I would run all four in it.
At 18” those lights put out 600ppfd, good for veg or a little higher at 20-24”.
For flower you will want to keep it in the 12”-16” range where it outputs roughly 750-1000ppfd.
Goodluck and cheers!