Stickanswered grow question 6 years ago Defoliation will prevent mold, it will help you to have a better control on your LST and setup a beautiful canopy. It will also increase the air-flow around your stems/buds, it will dramatically increase the speed of growth and create a more compact plant. Judging on your last pictures I'll say that defoliation is already possible, even more, it's required/highly recommended : your plants are healthy, they developed several nodes, they're bushy and it looks like some bottom branches can't get enough air & light. Go for it, keep us up to date and good luck with these beauties!