great question, difficult but not impossible, first of all 4 different pots with 4 plants will give you more yield even if small than 1-2 alone even if they are big later. Up to here it's positive. Your box is really small. My real question is do you really need the box? Because I'm currently doing 6 grows but only 1 is in a box. If you can't do without it, use LST, SCROG, pruning nets, etc.