In my humble opinion, you should defoliate if the area being shaded by the fan leaf is larger then the leaf itself, I mean, the shaded area would bring more energy to the plant then the defoliated leaf. that being said, I also think you should take the leaf if it's shading a bud. and you can take the little popcorn buds from the lower part of the plant, so the buds upstairs / next to the light would get more energy too. the thing with leaves is they receive and store energy, if you take too much the plant would be weakened even with lots of nuts available in the media, so be careful. I would advice to defoliate just before you flip to 12/12 (just a little bit, be careful) and after the stretch, around week 3, or 4, depending on the strain and conditions you are growing. oh, and you can take some leaves out by the very end of flowering, they should be all weared out.
Hope I could help.
Tchau, do Brazil =)